16 Oct 2025

The Oldest Woman Had “High” Cholesterol — Here’s What That Really Means

Nick Norwitz: A groundbreaking new study explored the biology of a 117-year-old woman, who passed last year as the oldest verified person at the time. Researchers analyzed her genome, metabolism, telomeres, mitochondria, lipid profile, and gut microbiome to uncover what made her a super-ager! We’ll explore her genetic resilience, mitochondrial health, autophagy profile, and her diet.

This is not about one “magic bullet” but about the synergy of genetics, lifestyle, and environment. Maria’s story offers valuable lessons for healthy aging, cardiovascular health, metabolic health, and gut health — and clues to why some people thrive beyond 110. Stay Curious as we break down this treasure trove of longevity science.

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